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In 1938 Albert Hoffman accidently discovered LSD while studying a fungus (ergot) that affected rye. Like Alexander Fleming who discovered penicillin by accident, he was trying to find a drug that whould help contain hemorrhaging for women who lost so much blood during childbirth.
During his first controlled experiment he ingested what he thought was a small amount, not knowing how potent LSD was he took 50 times more than he probably should have.
He detailed the effects he observed during his initial experimental ingestion describing trails, double images, elasticity of objects with heavily saturated melting colores, kaleidoscope-like effects where objects seemed to sway and curve as if reflections on moving water and auditory sounds which turned into moving visual imagery.
Brain scans of individuals taking LSD reveal that it allows parts of the cortex to become flooded with signals that are normally filtered out to prevent information overload.
The drug allows more information to flow from the thalamus, and it stops the flow of information to the temporal cortex.